A Wnt3a variant participates in chick apical ectodermal ridge formation: Distinct biological activities of Wnt3a splice variants in chick limb development
نویسندگان
چکیده
منابع مشابه
Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb.
We wish to understand how limbs are positioned with respect to the dorso-ventral axis of the body in vertebrate embryos, and how different regions of limb bud ectoderm, i.e. dorsal ectoderm, apical ridge and ventral ectoderm, originate. Signals from dorsal and ventral ectoderm control dorso-ventral patterning while the apical ectodermal ridge (AER) controls bud outgrowth and patterning along th...
متن کاملDistinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud.
The apical ectodermal ridge (AER) is an essential structure for vertebrate limb development. Wnt3a is expressed during the induction of the chick AER, and misexpression of Wnt3a induces ectopic expression of AER-specific genes in the limb ectoderm. The genes beta-catenin and Lef1 can mimic the effect of Wnt3a, and blocking the intrinsic Lef1 activity disrupts AER formation. Hence, Wnt3a functio...
متن کاملThe effect of removing posterior apical ectodermal ridge of the chick wing and leg on pattern formation.
Recent experiments, in which barriers were inserted between anterior and posterior tissues of the chick wing bud, resulted in deletion of structures anterior to the barrier (Summerbell, 1979). From these data it was concluded that blockage of morphogen from the polarizing zone by the barrier resulted in the observed failure of specification of anterior structures. We suggest an alternative inte...
متن کاملThe limb deformity gene is required for apical ectodermal ridge differentiation and anteroposterior limb pattern formation.
To gain insight into the role of the limb deformity (ld) gene in limb morphogenesis, we examined the morphologic details of early embryonic limb formation in the mutant ld/ld mouse. Initial morphological differences between wild-type and homozygous ld embryos are apparent during early gestational day 10, a time period during which anteroposterior limb morphogenesis occurs. As a result of a shor...
متن کاملA splice variant of CD44 expressed in the apical ectodermal ridge presents fibroblast growth factors to limb mesenchyme and is required for limb outgrowth.
Signals from the apical ectodermal ridge (AER) of the developing vertebrate limb, including fibroblast growth factor-8 (FGF-8), can maintain limb mesenchymal cells in a proliferative state. We report here that a specific CD44 splice variant is crucial for the proliferation of these mesenchymal cells. Epitopes carried by this variant colocalize temporally and spatially with FGF-8 in the AER thro...
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ژورنال
عنوان ژورنال: Development, Growth & Differentiation
سال: 2007
ISSN: 0012-1592,1440-169X
DOI: 10.1111/j.1440-169x.2007.00938.x